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Publications by year (2006-2016)
DNA Polymerases and DNA Repair
-Structural basis for an unexpected "in trans" templated activity by TdT: implications for V(D)J recombination and DNA double-strand-breaks repair in eukaryotes,
J. Loc'h, S. Rosario and M. Delarue, Structure (Sep 2016).
Pentameric Ligand-gated ion channels: drug binding sites in different conformational states
-X-ray structures of GLIC with Barbiturates, with Pr. Trevor Smart (UCL, UK) (J. Biol. Chem.).
-TdT structures in complex with a DNA synapsis shed new light on DNA Double-Strand-Break Repair by NHEJ (EMBO J., Mar 2015).
-Snapshots of Terminal deoxynucleotidyl transferase caught in action: dynamical aspects of the two-metal-ion mechanism (J. Gouge et al., J. Mol. Biol., Jul 2013)
-Structure of DNA pol B from P. abyssi in editing mode by J. Gouge et al. (JMB)
a web-based software to calculate SAXS spectra from PDB coordinates,
including the solvent density predicted by AquaSol, is now available on-line.
These sites provide online servers for algorithms such as normal mode
calculation, structural refinement, solvation, mutation and (later) transition path calculation.
Go to Main site for more details on the group activities.